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OALib Journal期刊

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UTILIZA O DO CONTROLE ESTATíSTICO DE PROCESSOS (CEP) COMO INDICADOR DE VIOLA O EM PROGRAMAS DE PAGAMENTO DO LEITE PELA QUALIDADE
Fabio Henrique Takahashi,Laerte Dagher Cassoli,Paulo Fernando Machado
Ciência Animal Brasileira , 2011,
Abstract: The aim of this study was to use the statistical process control (SPC) as a tool of recognition and rating for farms with larger probabilities of infraction of milk quality standards used by industry. Data of somatic cell count (SCC) and total bacterial count (TBC) from 452 farms were used. Proportion of infractions of quality standard was calculated considering limits of SCC = 400,000 cells/mL and TBC = 100,000 CFU/mL. Indices Cpk were calculated and farms were rated according to four categories of Cpk means and indices. The farms which presented larger means and standard deviation had larger frequencies of violation. Farms with means lower than limits proposed to SCC and TBC represented, respectively, 25.05 % and 97.78 % of farms. However, proportion of farms that provided milk consistently within the quality standards evaluated (Cpk ≥ 1) represented 4.65 % and 35.17 % of farms for SCC and TBC, respectively. Therefore, the Cpk index can be used by the industry associated with the current models to characterize milk quality from farms, since it identifies more consistent herds in producing quality-standard milk.
Experimental models of autoimmune inflammatory ocular diseases
Gasparin, Fabio;Takahashi, Beatriz Sayuri;Scolari, Mariana Ramos;Gasparin, Filipe;Pedral, Lycia Sampaio;Damico, Francisco Max;
Arquivos Brasileiros de Oftalmologia , 2012, DOI: 10.1590/S0004-27492012000200016
Abstract: ocular inflammation is one of the leading causes of blindness and loss of vision. human uveitis is a complex and heterogeneous group of diseases characterized by inflammation of intraocular tissues. the eye may be the only organ involved, or uveitis may be part of a systemic disease. a significant number of cases are of unknown etiology and are labeled idiopathic. animal models have been developed to the study of the physiopathogenesis of autoimmune uveitis due to the dif?culty in obtaining human eye inflamed tissues for experiments. most of those models are induced by injection of speci?c photoreceptors proteins (e.g., s-antigen, interphotoreceptor retinoid-binding protein, rhodopsin, recoverin, phosducin). non-retinal antigens, including melanin-associated proteins and myelin basic protein, are also good inducers of uveitis in animals. understanding the basic mechanisms and pathogenesis of autoimmune ocular diseases are essential for the development of new treatment approaches and therapeutic agents. the present review describes the main experimental models of autoimmune ocular inflammatory diseases.
New approaches and potential treatments for dry age-related macular degeneration
Damico, Francisco Max;Gasparin, Fabio;Scolari, Mariana Ramos;Pedral, Lycia Sampaio;Takahashi, Beatriz Sayuri;
Arquivos Brasileiros de Oftalmologia , 2012, DOI: 10.1590/S0004-27492012000100016
Abstract: emerging treatments for dry age-related macular degeneration (amd) and geographi c atrophy focus on two strategies that target components involved in physiopathological pathways: prevention of photoreceptors and retinal pigment epithelium loss (neuroprotection induction, oxidative damage prevention, and visual cycle modification) and suppression of inflammation. neuroprotective drugs, such as ciliary neurotrophic factor, brimonidine tartrate, tandospirone, and anti-amyloid β antibodies, aim to prevent apoptosis of retinal cells. oxidative stress and depletion of essential micronutrients are targeted by the age-related eye disease study (areds) formulation. visual cycle modulators reduce the activity of the photoreceptors and retinal accumulation of toxic fluorophores and lipofuscin. eyes with dry age-related macular degeneration present chronic inflammation and potential treatments include corticosteroid and complement inhibition. we review the current concepts and rationale of dry age-related macular degeneration treatment that will most likely include a combination of drugs targeting different pathways involved in the development and progression of age-related macular degeneration.
VARIA O E MONITORAMENTO DA QUALIDADE DO LEITE ATRAVéS DO CONTROLE ESTATíSTICO DE PROCESSOS
Fabio Henrique Takahashi,Laerte Dagher Cassoli,Aline Zampar,Paulo Fernando Machado
Ciência Animal Brasileira , 2012,
Abstract: The aim of this study was to evaluate the statistical process control (SPC) as an identification tool of non-natural effects on milk quality, which may be manipulated. Data of milk production, somatic cell count (SCC) and total bacterial count (TBC) from 384 farms were used. Natural effects (season and volume) on the variation of SCC and TBC were evaluated; furthermore, control charts of somatic cell score (SCS) and total bacterial count transformed (TBCt) were designed to find non-natural variation resources on four farms. It was observed that the season affected significantly the SCS and TBCt. Control charts, in each season, indicated the non-natural variation in SCS and TBCt on the four farms evaluated. Therefore, the application of SPC as a tool at farm level is an additional instrument for monitoring milk quality.
Emotion Interference Solves Social Dilemma  [PDF]
Taiki Takahashi
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.25083
Abstract: Roles of emotion in decision-making have been attracting attention in neuroeconomics and behavioral game theory. We mathematically demonstrate that “emotion interference”, a recently-discovered psychological phenomenon [1] helps to solve social dilemma in a one-shot prisoner’s dilemma game. Furthermore, the present theory also accounts for the violation of Savage’s sure-thing principle in the prisoner’s dilemma [2]. Furthermore, it is also explained that why people in the society with higher social mobility are more cooperative. Relations of the present work to recently evolving fields of neuroeconomics and quantum decision theory are discussed.
Multiple Intelligence Theory Can Help Promote Inclusive Education for Children with Intellectual Disabilities and Developmental Disorders: Historical Reviews of Intelligence Theory, Measurement Methods, and Suggestions for Inclusive Education  [PDF]
Junichi Takahashi
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.49086
Abstract:

Inclusive education, based on the principle that all children (including those with disabilities) should receive similar education, has been recently adopted in primary and secondary schools throughout several countries. Within an inclusive education context, teachers are faced with the challenge of developing their knowledge and skills necessary to properly assess the intellectual abilities of a wide range of children. Although intelligence has been examined for over 100 years, researchers are still debating what abilities should or should not be classified as belonging to the domain of intelligence. In order to effectively apply intelligence theory and assessment methods for inclusive education, we compared traditional intelligence theory (Spearman’s two-factor model) with a more recent intelligence theory (Gardner’s multiple intelligence theory). Spearman’s theory focuses on elementary perceptual processes by using the single g factor, whereas Gardner’s theory recognizes several types of intelligence. On the basis of these reviews, we propose the utility of multiple intelligence theory for inclusive education, considering the various profiles of intelligence shown by children with intellectual disabilities and developmental disorders.

Suggestions for a Teacher Training Program for Inclusive Education in a Japanese University  [PDF]
Junichi Takahashi
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.48074
Abstract:

Inclusive education has been recently proposed in primary and secondary educations in many countries. Children who need special education support should be educated together with typically developing children in general classes. Although many studies have examined the effectiveness of inclusive education, researchers have pointed out that some general education teachers experience problems in their relationships with children who have disabilities such as developmental disorders and intellectual disabilities. In this paper, we review teacher training programs in a Japanese university and offer suggestions to enhance teachers’ relationships with disabled children. In our discussion, we focused on adult attachment theory, which is an affective connection and interactions between self and others. First, we reviewed the importance of teachers’ relationships with disabled children. Second, we reviewed attachment theories with respect to the quality of teacher-child relationships, and lastly, we proposed that adult attachment theory is a mediator in the quality of teacher-child relationships. We proposed a direction for the application of these conceptual assumptions to the teacher-training program for inclusive education in a Japanese university.

The q-Exponential Social Discounting Functions of Gain and Loss  [PDF]
Taiki Takahashi
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.43066
Abstract:

Social discounting has been attracting attention in behavioral psychology, econophysics, and neuroeconomics. Several mathematical models have been proposed for social discounting; exponential discounting, hyperbolic discounting, a q-exponential discounting model based on Tsallis’ statistics. In order to experimentally examine the mathematical characteristics of the q-exponential social discounting models for gain and loss in humans, we estimated the parameters of the q-exponential social discounting models by assessing the points of subjective equality (indifference points) at seven social distances. We observed that gain was more steeply social-discounted than loss. Usefulness of the q-exponential social discounting model in social physics, econophysics, and cultural neuroeconomics are discussed.

Excessive Base Money and Global Financial Crisis in Relation to the Essence of the So-Called “Abenomics”  [PDF]
Goro Takahashi
Journal of Financial Risk Management (JFRM) , 2013, DOI: 10.4236/jfrm.2013.24013
Abstract: After the financial crisis of 2008, we are facing possibility of a global financial crisis further. Most of the financial crises have occurred in situations when there is so much money in the financial market, but they have not often occurred in cases when the market does not have enough money. This thought, however, is not general common sense in the financial academic field. Based on general understanding, the cause of financial crisis is the lack of money with the rise of interest rates in the financial market. If the lack of money is the reason for financial crisis, then we have never met with any financial crisis, because most leading countries have much money in the financial market in nowadays. According to theory of Economics, government deficit plus current account surplus means surplus of savings in the private sector of the country. Currently, most countries with big-scale economy have big deficits in their national accounts. But there is enough money in the business sector. I focus on this aspect and then analyze the base money policy of the central bank of some countries, and analyze its effect or the meaning of excessive base money in the financial market. As a general economic rule, the excess of money in a financial market causes a low interest rate. On the other hand, governments are faced with less money. If enough money in the money market flows to the treasury account, the government gets national fiscal balance. But it is not easy for most governments to create the balance. The reason behind this is the failure of a national economic and fiscal policy, including tax policy. Many countries and communities are facing problems with the flow of money from the private sector to the government. This problem is one of the biggest international issues which should be solved immediately (Taylor, 2009). Of course, we cannot neglect the fact that there are countries having little money even their private sector like Greece, Italy, Spain, and so on. Economic growth is the only measure to solve the financial problem in these countries. I do not consider these countries in this paper. The financial markets that I focus on in this paper are the US, the EURO Area, China and Japan. Many experts and economic politician worldwide consider “Abenomics” noteworthy. It aims at increasing base money in the financial market of Japan. The biggest purpose of this policy is for breaking away from deflation. Japanese Prime minister Abe also expects devaluation of the Yen, and increase in Japanese export. Later in this paper, we will see that the amount of
Two-water-assisted racemization of the succinimide intermediate formed in proteins. A computational model study  [PDF]
Ohgi Takahashi
Health (Health) , 2013, DOI: 10.4236/health.2013.512273
Abstract:

Racemization of aspartic acid (Asp) residues in proteins plays an important role in the molecular biology of aging. In the widely accepted mechanism of the Asp racemization, a succinimide (SI) intermediate is the species which actually undergo the direct racemization. In the present study, a two-water-assisted mechanism of the SI racemization was computationally investigated using a model compound in which an aminosuccinyl (Asu) residue is capped with acetyl and NMe groups on the N-and C-termini, respectively. The two water molecules catalyze the enolization of the Hα-Cα-C=O portion in the Asu residue by mediating proton relay from the α-carbon atom to the carboxyl oxygen atom. After the enolization, migration of the water molecules and conformational change lead to the mirror image of the initially formed enol two-water complex, and the racemization is completed by the following ketonization. The overall activation barrier (28.2 kcal·mol-1) corresponds to the enolization and ketonization steps, and falls within the available experimental activation energies (21.4-29.0 kcal·mol-1). Therefore, the two-water-assisted mechanism investigated here is plausible for the in vivo and in vitro racemization reactions of the SI intermediates formed in peptides and proteins.

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